ࡱ> )` R!bjbj;L{{7n n n n n n n  8|:, QZrL"-ֶfhZn C C C n n  &&&C <n n &C &&Šn n f `t$M`!0Qlmm%$mrmn  o&]Z&dQC C C C    n n n n n n  Curriculum Vitae of Hua Zhang Date of Birth: 1980-12-16 Gender: MaleMarital status: Married, with 2 daughters, 4-year-old and 0-year-old.Civil Status: Chinese citizen Current position: Senior researcher at the Department of Chemistry and Molecular Biology, University of Gothenburg.Ph.D. degree: Physiology, China Agricultural University, China, December 18, 2008. Education & CareerJune 1999September 2003: B.Sc. student at the College of Bioscience, China Agricultural University, China.September 2003December 2008: Ph.D student at the College of Bioscience, China Agricultural University, China.January 2009June 2010: Research assistant at the College of Bioscience, China Agricultural University, China. June 2010December 2011: Postdoctoral researcher at the Department of Medical Biochemistry and Biophysics, Ume University, Sweden.December 2011-present: Senior researcher at the Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden. Participated projectsChinese 863 Project, China, (2006-2011): Ovarian development and ovarian disease.The National Natural Science Foundation, China, (2006-2008): The role of CYP51, the key synthase of Meiotic activated steroids (MAS), in meiotic mature of mice oocytes.National Basic Research Program of China, China, (2008-2010): The regulated mechanism of mouse folliculogenesis and oogenesis.Chinese 973 Project, China, (2009-2014): Oogenesis and aging. Supported project:Swedish Research Council (20102014): Studies of signaling molecules in oocytes that affect the physiological and pathological changes of the ovary. Conference Abstract Speaker at the Annual Meeting of national animal physiology and chemistry academy, Shanxi, China, July 28 - 30, 2008 Hua Zhang, Huirong Xie, Jing Wen, Ge Li, Bo Zhou, Meijia Zhang and Guoliang Xia. 2004. Meiosis Activating Sterols regulates the mouse primordial folliculogenesis. 10th Annual Meeting of National Animal physiology and chemistry academy, p139 (Beijing, China) Lei Lei, Hua Zhang, Fengchao Wang, Shiying Jin, Maoyong Fu, Guoliang Xia, Hainbin Wang. 2005. Stage specific acquiring the follicle forming ability of female germ cells in fetal mouse. First Sino-Canada Bilateral Workshop on Reproductive Health Research, p51 (Beijing, China) Publication list of Hua ZhangHua Zhang, Sanjiv Risal, Nagaraju Gorre, Kiran Busayavalasa, Xin Li, Yan Shen, Mats Brnnstrm, and Kui Liu. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice. Current Biology, 2014 Nov 03; 24(21):2501-8Hua Zhang*, Wenjing Zheng*, Yan Shen, Deepak Adhikari, and Kui Liu. Experimental evidence showing that no mitotically active female germline progenitors exist in postnatal mouse ovaries. Proceedings of the National Academy of Sciences of the United States of America, 2012 Jul 31;109(31):12580-5 Wenjing Zheng*, Hua Zhang*, Gorre Najaraju, Sanjiv Risal, Yan Shen, Kui Liu. Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions. Hum Mol Genet. 2014 Feb 15;23(4):920-8Hua Zhang, Deepak Adhikari, Wenjing Zheng, and Kui Liu. Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells. Reproduction, 2013 Oct 21;146(6):R229-33. ReviewHua Zhang, Baoshan Xu, Huirong Xie, Bo Zhou, Hong Ouyang, Gang Ning, Ge Li, Meijia Zhang and Guoliang Xia. HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/18937335?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum"Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. Molecular Reproduction and Development. 2009 May;76:514-21Wenjing Zheng, Hua Zhang, Kui Liu. The two classes of primordial follicles in the mouse ovary: their development, physiological functions and implications for future research. Mol Hum Reprod. 2014 Apr;20(4):286-92. ReviewGe Li*, Hua Zhang*, Yijing Wang, Jing Wen, Zhen Teng, Guoping Mao, Jianwei Wang, Meng Guo, Xinyi Mu, Guoliang Xia.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/21622111" Stage-specific mice ovarian somatic cell is involved in primordial folliculogenesis. Frontiers in Bioscience (Elite Ed). 2011 Jun 1;3:1025-33.Meng Guo, Hua Zhang, Fenghua Bian, Ge Li, Xinyi Mu, Jing Wen, Guankun Mao, Zhen Teng, Guoliang Xia, Meijia Zhang. Progesterone down-regulates the expression of Jagged2 and Notch1, which are involved in primordial follicle formation in the mouse ovary. Frontiers in Bioscience (Elite Ed). 2012 Jun 1;4:2731-44.Jing Wen, Hua Zhang, Ge Li, Guanping Mao, Xiufen Chen, Jianwei Wang, Meng Guo, Xinyi Mu, Hong Ouyang, Meijia Zhang, Guoliang Xia.  HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/19809506" PAR6, a potential marker for the germ cells selected to form primordial follicles in mouse ovary. PLoS One. 2009 Oct 7;4(10):e7372Lei Lei, Hua Zhang, Shiying Jin, Fengchao Wang, Maoyong Fu, Haibin Wang, Guoliang Xia.HYPERLINK "http://www.ncbi.nlm.nih.gov/pubmed/16741957?ordinalpos=18&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum" Stage-specific germ-somatic cell interaction directs the primordial folliculogenesis in mouse fetal ovaries. Journal of Cellular Physiology. 2006 Sep;208(3):640-7Adhikari D, Gorre N, Risal S, Zhao Z, Zhang H, Shen Y, Liu K. The safe use of a PTEN inhibitor for the activation of dormant mouse primordial follicles and generation of fertilizable eggs. PLoS One. 2012;7(6):e39034Gang Ning, Hong Ouyang, Songbo Wang, Xiufen Chen, Baoshan Xu, Jiange Yang, Hua Zhang, Meijia Zhang, and Guoliang Xia. 3',5'-cyclic adenosine monophosphate response element binding protein up-regulated cytochrome P450 lanosterol 14alpha-demethylase expression involved in follicle-stimulating hormone-induced mouse oocyte maturation. Molecular Endocrinology. 2008 Jul; 22(7):1682-94. Songbo Wang, Gang Ning, Xiufen Chen, Jiange Yang, Hong Ouyang, Hua Zhang, Ping Tai, Xinyi Mu, Bo Zhou, Meijia Zhang, Guoliang Xia. PDE5 modulates oocyte spontaneous maturation via cGMP-cAMP but not cGMP-PKG signaling. Frontiers in Bioscience. 2008 May 1; 13:7087-95.Jun Yan, Bo Zhou, Jie Yang, Ping Tai, Xiufen Chen, Hua Zhang, Meijia Zhang, Guoliang Xia. Glucose can reverse the effects of acute fasting on mouse ovulation and oocyte maturation. 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